β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.

β-Arrestin2 regulates lysophosphatidic acid-induced human breast tumor cell migration and invasion via Rap1 and IQGAP1.

β-Arrestins play critical roles in chemotaxis and cytoskeletal reorganization downstream of several receptor types, including G protein-coupled receptors (GPCRs), which are targets for greater than 50% of all pharmaceuticals. Among them, receptors for lysophosphatidic acid (LPA), namely LPA(1) are o...

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Bibliographic Details
Main Authors: Mistre Alemayehu, Magdalena Dragan, Cynthia Pape, Iram Siddiqui, David B Sacks, Gianni M Di Guglielmo, Andy V Babwah, Moshmi Bhattacharya
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3566084?pdf=render

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http://europepmc.org/articles/PMC3566084?pdf=render

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