Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients

Unraveling Human AQP5-PIP Molecular Interaction and Effect on AQP5 Salivary Glands Localization in SS Patients

Saliva secretion requires effective translocation of aquaporin 5 (AQP5) water channel to the salivary glands (SGs) acinar apical membrane. Patients with Sjögren’s syndrome (SS) display abnormal AQP5 localization within acinar cells from SGs that correlate with sicca manifestation and glands hypofunc...

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Bibliographic Details
Main Authors: Clara Chivasso, Veronika Nesverova, Michael Järvå, Anne Blanchard, Kristie L Rose, Fredrik Kryh Öberg, Zhen Wang, Maud Martin, Florent Lhotellerie, Egor Zindy, Bruna Junqueira, Karelle Leroy, Benoit Vanhollebeke, Valérie Delforge, Nargis Bolaky, Jason Perret, Muhammad Shahnawaz Soyfoo, Stefania Moscato, Chiara Baldini, François Chaumont, Letizia Mattii, Kevin L Schey, Yvonne Myal, Susanna Törnroth-Horsefield, Christine Delporte
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
aquaporin-5
Sjögren’s syndrome
prolactin-inducible protein
salivary gland
Online Access:https://www.mdpi.com/2073-4409/10/8/2108

Internet

https://www.mdpi.com/2073-4409/10/8/2108

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