Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contr...

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Bibliographic Details
Main Authors:	Matthew J. Birket, Marcelo C. Ribeiro, Georgios Kosmidis, Dorien Ward, Ana Rita Leitoguinho, Vera van de Pol, Cheryl Dambrot, Harsha D. Devalla, Richard P. Davis, Pier G. Mastroberardino, Douwe E. Atsma, Robert Passier, Christine L. Mummery
Format:	Article
Language:	English
Published:	Elsevier 2015-10-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124715010360

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http://www.sciencedirect.com/science/article/pii/S2211124715010360

Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function

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