Contractile Defect Caused by Mutation in MYBPC3 Revealed under Conditions Optimized for Human PSC-Cardiomyocyte Function
Maximizing baseline function of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) is essential for their effective application in models of cardiac toxicity and disease. Here, we aimed to identify factors that would promote an adequate level of function to permit robust single-cell contr...
Main Authors: | Matthew J. Birket, Marcelo C. Ribeiro, Georgios Kosmidis, Dorien Ward, Ana Rita Leitoguinho, Vera van de Pol, Cheryl Dambrot, Harsha D. Devalla, Richard P. Davis, Pier G. Mastroberardino, Douwe E. Atsma, Robert Passier, Christine L. Mummery |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-10-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715010360 |
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