Ploidy status and copy number aberrations in primary glioblastomas defined by integrated analysis of allelic ratios, signal ratios and loss of heterozygosity using 500K SNP Mapping Arrays

<p>Abstract</p> <p>Background</p> <p>Genomic hybridization platforms, including BAC-CGH and genotyping arrays, have been used to estimate chromosome copy number (CN) in tumor samples by detecting the relative strength of genomic signal. The methods rely on the assumptio...

Full description

Bibliographic Details
Main Authors: Cowell John K, Lee Walter, Lo Ken C, Gardina Paul J, Turpaz Yaron
Format: Article
Language:English
Published: BMC 2008-10-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/9/489