IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

IGF-1R Promotes Symmetric Self-Renewal and Migration of Alkaline Phosphatase+ Germ Stem Cells through HIF-2α-OCT4/CXCR4 Loop under Hypoxia

Summary: Hypoxia cooperates with endocrine signaling to maintain the symmetric self-renewal proliferation and migration of embryonic germline stem cells (GSCs). However, the lack of an appropriate in vitro cell model has dramatically hindered the understanding of the mechanism underlying this cooper...

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Bibliographic Details
Main Authors: Yung-Che Kuo, Heng-Kien Au, Jue-Liang Hsu, Hsiao-Feng Wang, Chiung-Ju Lee, Syue-Wei Peng, Ssu-Chuan Lai, Yu-Chih Wu, Hong-Nerng Ho, Yen-Hua Huang
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671117305519

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http://www.sciencedirect.com/science/article/pii/S2213671117305519

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