Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme

Single nucleotide variants lead to dysregulation of the human mitochondrial NAD(P)+-dependent malic enzyme

Summary: Human mitochondrial NAD(P)+-dependent malic enzyme (ME2) is well recognized to associate with cancer cell metabolism, and the single nucleotide variants (SNVs) of ME2 may play a role in enzyme regulation. Here we reported that the SNVs of ME2 occurring in the allosteric sites lead to inacti...

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Bibliographic Details
Main Authors: Ju-Yi Hsieh, Hao-Ping Yang, Sunil Kumar Tewary, Hui-Chen Cheng, Yi-Liang Liu, Shih-Chieh Tai, Wei-Lin Chen, Chien-Hui Hsu, Ting-Jhen Huang, Chuan-Jung Chou, Yu-Nan Huang, Ching-Tien Peng, Meng-Chiao Ho, Guang-Yaw Liu, Hui-Chih Hung
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:iScience
Subjects:
Biological Sciences
Genetics
Cell Biology
Structural Biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422100002X

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http://www.sciencedirect.com/science/article/pii/S258900422100002X

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