Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection

CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted in...

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Bibliographic Details
Main Authors: Enya Qing, Michael Hantak, Stanley Perlman, Tom Gallagher
Format: Article
Language:English
Published: American Society for Microbiology 2020-02-01
Series:mBio
Subjects:
Online Access:https://doi.org/10.1128/mBio.02764-19