Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

Circulating myeloid cells invade the central nervous system to mediate cachexia during pancreatic cancer

Weight loss and anorexia are common symptoms in cancer patients that occur prior to initiation of cancer therapy. Inflammation in the brain is a driver of these symptoms, yet cellular sources of neuroinflammation during malignancy are unknown. In a mouse model of pancreatic ductal adenocarcinoma (PD...

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Bibliographic Details
Main Authors: Kevin G Burfeind, Xinxia Zhu, Mason A Norgard, Peter R Levasseur, Christian Huisman, Abigail C Buenafe, Brennan Olson, Katherine A Michaelis, Eileen RS Torres, Sophia Jeng, Shannon McWeeney, Jacob Raber, Daniel L Marks
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-05-01
Series:eLife
Subjects:
cachexia
neuroimmunology
neutrophils
brain
pancreatic cancer
myeloid cells
Online Access:https://elifesciences.org/articles/54095

Internet

https://elifesciences.org/articles/54095

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