Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements

Multiple Recombination Events and Strong Purifying Selection at the Origin of SARS-CoV-2 Spike Glycoprotein Increased Correlated Dynamic Movements

Our evolutionary and structural analyses revealed that the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) spike gene is a complex mosaic resulting from several recombination events. Additionally, the fixation of variants has mainly been driven by purifying selection, suggesting...

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Bibliographic Details
Main Authors: Massimiliano S. Tagliamonte, Nabil Abid, Stefano Borocci, Elisa Sangiovanni, David A. Ostrov, Sergei L. Kosakovsky Pond, Marco Salemi, Giovanni Chillemi, Carla Mavian
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
SARS-CoV-2
COVID-19
recombination
furin-like cleavage site
ACE2
S glycoprotein
Online Access:https://www.mdpi.com/1422-0067/22/1/80

Internet

https://www.mdpi.com/1422-0067/22/1/80

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