All-Trans Retinoic Acid Attenuates Fibrotic Processes by Downregulating TGF-β1/Smad3 in Early Diabetic Nephropathy

All-Trans Retinoic Acid Attenuates Fibrotic Processes by Downregulating TGF-β1/Smad3 in Early Diabetic Nephropathy

Diabetic nephropathy (DN) involves damage associated to hyperglycemia and oxidative stress. Renal fibrosis is a major pathologic feature of DN. The aim of this study was to evaluate anti-fibrogenic and renoprotective effects of all-trans retinoic acid (ATRA) in isolated glomeruli and proximal tubule...

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Bibliographic Details
Main Authors: Edith Sierra-Mondragon, Rafael Rodríguez-Muñoz, Carmen Namorado-Tonix, Eduardo Molina-Jijon, Daniel Romero-Trejo, Jose Pedraza-Chaverri, Jose L. Reyes
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
extracellular matrix
renal fibrosis
retinoic acid receptor
glomeruli
proximal tubules
Online Access:https://www.mdpi.com/2218-273X/9/10/525

Internet

https://www.mdpi.com/2218-273X/9/10/525

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