Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

Influence of verapamil on the pharmacokinetics of rotundic acid in rats and its potential mechanism

Context Rotundic acid (RA), a plant-derived pentacyclic triterpene acid, has been reported to possess extensive pharmacological activities. The poor bioavailability limits its further development and potential clinic application. Objective To clarify the potential mechanism for poor oral bioavailabi...

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Bibliographic Details
Main Authors: Haihua Shang, Ze Wang, Hong Ma, Yinghui Sun, Xiaoyan Ci, Yuan Gu, Changxiao Liu, Duanyun Si
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Pharmaceutical Biology
Subjects:
drug–drug interaction
cyp3a
p-gp
oral bioavailability
Online Access:http://dx.doi.org/10.1080/13880209.2021.1871634

Internet

http://dx.doi.org/10.1080/13880209.2021.1871634

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