Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.

Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats.

In the R6/2 mouse model of Huntington's disease (HD), expansion of the CAG trinucleotide repeat length beyond about 300 repeats induces a novel phenotype associated with a reduction in transcription of the transgene.We analysed the structure of polymerase chain reaction (PCR)-generated DNA cont...

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Bibliographic Details
Main Authors: Daniel Duzdevich, Jinliang Li, Jhoon Whang, Hirohide Takahashi, Kunio Takeyasu, David T F Dryden, A Jennifer Morton, J Michael Edwardson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3037965?pdf=render

Internet

http://europepmc.org/articles/PMC3037965?pdf=render

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