Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids

Synthesis of Chiral 1,4-Disubstituted-1,2,3-Triazole Derivatives from Amino Acids

A versatile method for the synthesis of chiral 1,4-disubstituted-1,2,3-triazole derivatives starting from easily accessible naturally occurring D-or L-amino acids as chiral synthons is described. The amino acids were converted into azido alcohols, followed by copper catalyzed [3+2] cycloaddition rea...

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Bibliographic Details
Main Authors: Morten Grøtli, Peter Dinér, Karin Krainz, Itedale Namro Redwan, Michael Klein
Format: Article
Language:English
Published: MDPI AG 2009-12-01
Series:Molecules
Subjects:
[3+2] cycloaddition
azido alcohols
1,4-disubstituted-1,2,3-triazoles
Online Access:http://www.mdpi.com/1420-3049/14/12/5124/

Internet

http://www.mdpi.com/1420-3049/14/12/5124/

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