Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model

Severe Hepatic Insulin Resistance Induces Vascular Dysfunction: Improvement by Liver-Specific Insulin Receptor Isoform A Gene Therapy in a Murine Diabetic Model

Background: Cardiovascular dysfunction is linked to insulin-resistant states. In this paper, we analyzed whether the severe hepatic insulin resistance of an inducible liver-specific insulin receptor knockout (iLIRKO) might generate vascular insulin resistance and dysfunction, and whether insulin rec...

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Bibliographic Details
Main Authors: Almudena Gómez-Hernández, Natalia de las Heras, Andrea R. López-Pastor, Gema García-Gómez, Jorge Infante-Menéndez, Paula González-López, Tamara González-Illanes, Vicente Lahera, Manuel Benito, Óscar Escribano
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
insulin resistance
endothelial dysfunction
atherosclerosis
gene therapy
Online Access:https://www.mdpi.com/2073-4409/10/8/2035

Internet

https://www.mdpi.com/2073-4409/10/8/2035

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