Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.

Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia.

BACKGROUND:Children with acute lymphoblastic leukemia (ALL) often suffer from toxicity of chemotherapeutic drugs such as Methotrexate (MTX). Previously, we reported that 20% of patients receiving high-dose MTX developed oral mucositis. MTX inhibits folate metabolism, which is essential for DNA methy...

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Bibliographic Details
Main Authors: Natanja Oosterom, Pieter H Griffioen, Marissa A H den Hoed, Rob Pieters, Robert de Jonge, Wim J E Tissing, Marry M van den Heuvel-Eibrink, Sandra G Heil
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6037363?pdf=render

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http://europepmc.org/articles/PMC6037363?pdf=render

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