Phagocytic superoxide specifically damages an extracytoplasmic target to inhibit or kill Salmonella.

The phagocytic oxidative burst is a primary effector of innate immunity that protects against bacterial infection. However, the mechanism by which reactive oxygen species (ROS) kill or inhibit bacteria is not known. It is often assumed that DNA is a primary target of oxidative damage, consistent wit...

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Bibliographic Details
Main Authors: Maureen Craig, James M Slauch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2654757?pdf=render