Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus replicase. These proteins also interact with nume...

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Bibliographic Details
Main Authors: Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Viruses
Subjects:
alphavirus
Chikungunya virus
CD2AP
SH3KBP1
SH3 ligand
proteomics
Online Access:http://www.mdpi.com/1999-4915/10/5/226

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