aBravo Is a Novel <i>Aedes aegypti</i> Antiviral Protein that Interacts with, but Acts Independently of, the Exogenous siRNA Pathway Effector Dicer 2

by Margus Varjak, Rommel J. Gestuveo, Richard Burchmore, Esther Schnettler, Alain Kohl
Published 2020-07-01

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.

by Leena Pohjala, Age Utt, Margus Varjak, Aleksei Lulla, Andres Merits, Tero Ahola, Päivi Tammela
Published 2011-01-01

Mutational analysis of Rift Valley fever phlebovirus nucleocapsid protein indicates novel conserved, functional amino acids.

by Timothy J Mottram, Ping Li, Isabelle Dietrich, Xiaohong Shi, Benjamin Brennan, Margus Varjak, Alain Kohl
Published 2017-12-01

Spindle-E Acts Antivirally Against Alphaviruses in Mosquito Cells

by Margus Varjak, Isabelle Dietrich, Vattipally B. Sreenu, Bethan Eluned Till, Andres Merits, Alain Kohl, Esther Schnettler
Published 2018-02-01

Characterization of the Zika virus induced small RNA response in Aedes aegypti cells.

by Margus Varjak, Claire L Donald, Timothy J Mottram, Vattipally B Sreenu, Andres Merits, Kevin Maringer, Esther Schnettler, Alain Kohl
Published 2017-10-01

Antiviral RNA Interference Activity in Cells of the Predatory Mosquito, <i>Toxorhynchites amboinensis</i>

by Claire L. Donald, Margus Varjak, Eric Roberto Guimarães Rocha Aguiar, João T. Marques, Vattipally B. Sreenu, Esther Schnettler, Alain Kohl
Published 2018-12-01

Analysis of Zika virus capsid-Aedes aegypti mosquito interactome reveals pro-viral host factors critical for establishing infection

by Rommel J. Gestuveo, Jamie Royle, Claire L. Donald, Douglas J. Lamont, Edward C. Hutchinson, Andres Merits, Alain Kohl, Margus Varjak
Published 2021-05-01

Glucose-Regulated Protein 78 Interacts with Zika Virus Envelope Protein and Contributes to a Productive Infection

by Jamie Royle, Carolina Ramírez-Santana, Snezhana Akpunarlieva, Claire L. Donald, Rommel J. Gestuveo, Juan-Manuel Anaya, Andres Merits, Richard Burchmore, Alain Kohl, Margus Varjak
Published 2020-05-01

An <i>Aedes aegypti</i>-Derived Ago2 Knockout Cell Line to Investigate Arbovirus Infections

by Christina Scherer, Jack Knowles, Vattipally B. Sreenu, Anthony C. Fredericks, Janina Fuss, Kevin Maringer, Ana Fernandez-Sesma, Andres Merits, Margus Varjak, Alain Kohl, Esther Schnettler
Published 2021-06-01

Wolbachia Blocks Viral Genome Replication Early in Infection without a Transcriptional Response by the Endosymbiont or Host Small RNA Pathways.

by Stephanie M Rainey, Julien Martinez, Melanie McFarlane, Punita Juneja, Peter Sarkies, Aleksei Lulla, Esther Schnettler, Margus Varjak, Andres Merits, Eric A Miska, Francis M Jiggins, Alain Kohl
Published 2016-04-01

Mutation of CD2AP and SH3KBP1 Binding Motif in Alphavirus nsP3 Hypervariable Domain Results in Attenuated Virus

by Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak
Published 2018-04-01

Phenoloxidase activity acts as a mosquito innate immune response against infection with Semliki Forest virus.

by Julio Rodriguez-Andres, Seema Rani, Margus Varjak, Margo E Chase-Topping, Markus H Beck, Mhairi C Ferguson, Esther Schnettler, Rennos Fragkoudis, Gerald Barry, Andres Merits, John K Fazakerley, Michael R Strand, Alain Kohl
Published 2012-01-01

Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses

by Margus Varjak, Kevin Maringer, Mick Watson, Vattipally B. Sreenu, Anthony C. Fredericks, Emilie Pondeville, Claire L. Donald, Jelle Sterk, Joy Kean, Marie Vazeille, Anna-Bella Failloux, Alain Kohl, Esther Schnettler, W. Paul Duprex
Published 2017-05-01

A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs

by Alexander Karlas, Stefano Berre, Thérèse Couderc, Margus Varjak, Peter Braun, Michael Meyer, Nicolas Gangneux, Liis Karo-Astover, Friderike Weege, Martin Raftery, Günther Schönrich, Uwe Klemm, Anne Wurzlbauer, Franz Bracher, Andres Merits, Thomas F. Meyer, Marc Lecuit
Published 2016-05-01

The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression

by Melanie McFarlane, Floriane Almire, Joy Kean, Claire L. Donald, Alma McDonald, Bryan Wee, Mathilde Lauréti, Margus Varjak, Sandra Terry, Marie Vazeille, Rommel J. Gestuveo, Isabelle Dietrich, Colin Loney, Anna-Bella Failloux, Esther Schnettler, Emilie Pondeville, Alain Kohl
Published 2020-04-01

Full Genome Sequence and sfRNA Interferon Antagonist Activity of Zika Virus from Recife, Brazil.

by Claire L Donald, Benjamin Brennan, Stephanie L Cumberworth, Veronica V Rezelj, Jordan J Clark, Marli T Cordeiro, Rafael Freitas de Oliveira França, Lindomar J Pena, Gavin S Wilkie, Ana Da Silva Filipe, Christopher Davis, Joseph Hughes, Margus Varjak, Martin Selinger, Luíza Zuvanov, Ania M Owsianka, Arvind H Patel, John McLauchlan, Brett D Lindenbach, Gamou Fall, Amadou A Sall, Roman Biek, Jan Rehwinkel, Esther Schnettler, Alain Kohl
Published 2016-10-01

A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research.

by Suzannah J Rihn, Andres Merits, Siddharth Bakshi, Matthew L Turnbull, Arthur Wickenhagen, Akira J T Alexander, Carla Baillie, Benjamin Brennan, Fiona Brown, Kirstyn Brunker, Steven R Bryden, Kerry A Burness, Stephen Carmichael, Sarah J Cole, Vanessa M Cowton, Paul Davies, Chris Davis, Giuditta De Lorenzo, Claire L Donald, Mark Dorward, James I Dunlop, Matthew Elliott, Mazigh Fares, Ana da Silva Filipe, Joseph R Freitas, Wilhelm Furnon, Rommel J Gestuveo, Anna Geyer, Daniel Giesel, Daniel M Goldfarb, Nicola Goodman, Rory Gunson, C James Hastie, Vanessa Herder, Joseph Hughes, Clare Johnson, Natasha Johnson, Alain Kohl, Karen Kerr, Hannah Leech, Laura Sandra Lello, Kathy Li, Gauthier Lieber, Xiang Liu, Rajendra Lingala, Colin Loney, Daniel Mair, Marion J McElwee, Steven McFarlane, Jenna Nichols, Kyriaki Nomikou, Anne Orr, Richard J Orton, Massimo Palmarini, Yasmin A Parr, Rute Maria Pinto, Samantha Raggett, Elaine Reid, David L Robertson, Jamie Royle, Natalia Cameron-Ruiz, James G Shepherd, Katherine Smollett, Douglas G Stewart, Meredith Stewart, Elena Sugrue, Agnieszka M Szemiel, Aislynn Taggart, Emma C Thomson, Lily Tong, Leah S Torrie, Rachel Toth, Margus Varjak, Sainan Wang, Stuart G Wilkinson, Paul G Wyatt, Eva Zusinaite, Dario R Alessi, Arvind H Patel, Ali Zaid, Sam J Wilson, Suresh Mahalingam
Published 2021-02-01