Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

Mitragynine (Kratom)-Induced Cognitive Impairments in Mice Resemble Δ9-THC and Morphine Effects: Reversal by Cannabinoid CB1 Receptor Antagonism

Kratom is a widely abused plant-based drug preparation with a global interest in recent years, well beyond its native grounds in Southeast Asia. Mitragynine, its major psychoactive constituent is known to exhibit opioid-like behavioral effects with resultant neuroplasticity in the brain reward syste...

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Bibliographic Details
Main Authors: Ismail Nurul Iman, Nur Aimi Zawami Ahmad, Nurul Aiman Mohd Yusof, Ummi Nasrah Talib, Anwar Norazit, Jaya Kumar, Muhammad Zulfadli Mehat, Zurina Hassan, Christian P. Müller, Mustapha Muzaimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
kratom
mitragynine
morphine
Δ9-tetrahydrocannabinol (THC)
cannabinoid receptor 1 (CB1)
cognition
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.708055/full

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https://www.frontiersin.org/articles/10.3389/fphar.2021.708055/full

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