Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

Defective formyl peptide receptor 2/3 and annexin A1 expressions associated with M2a polarization of blood immune cells in patients with chronic obstructive pulmonary disease

Abstract Background Controversy exists in previous studies on macrophage M1/M2 polarization in chronic obstructive pulmonary disease (COPD). We hypothesized that formyl peptide receptor (FPR), a marker of efferocytosis and mediator of M1/M2 polarization, may be involved in the development of COPD. M...

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Bibliographic Details
Main Authors: Yung-Che Chen, Meng-Chih Lin, Chih-Hung Lee, Shih-Feng Liu, Chin-Chou Wang, Wen-Feng Fang, Tung-Ying Chao, Chao-Chien Wu, Yu-Feng Wei, Huang-Chih Chang, Chia-Cheng Tsen, Hung-Chen Chen, Taiwan Clinical Trial Consortium of Respiratory Disease (TCORE) group
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Journal of Translational Medicine
Subjects:
Formyl peptide receptor 1/2/3
M2a polarization
Chronic obstructive pulmonary disease
Cigarette smoking
Annexin A1
Online Access:http://link.springer.com/article/10.1186/s12967-018-1435-5

Internet

http://link.springer.com/article/10.1186/s12967-018-1435-5

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