Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.

Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.

The prion protein (PrP) is implicated in the Transmissible Spongiform Encephalopathies (TSEs), which comprise a group of fatal neurodegenerative diseases affecting humans and other mammals. Conversion of cellular PrP (PrP(C)) into the scrapie form (PrP(Sc)) is the hallmark of TSEs. Once formed, PrP(...

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Bibliographic Details
Main Authors: Natalia C Ferreira, Icaro A Marques, Wesley A Conceição, Bruno Macedo, Clarice S Machado, Alessandra Mascarello, Louise Domeneghini Chiaradia-Delatorre, Rosendo Augusto Yunes, Ricardo José Nunes, Andrew G Hughson, Lynne D Raymond, Pedro G Pascutti, Byron Caughey, Yraima Cordeiro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400098/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24400098/pdf/?tool=EBI

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