The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter

The Long Noncoding RNA HEAL Regulates HIV-1 Replication through Epigenetic Regulation of the HIV-1 Promoter

Despite our increased understanding of the functions of lncRNAs, their potential to develop HIV/AIDS cure strategies remains unexplored. A genome-wide analysis of lncRNAs in HIV-1-infected primary monocyte-derived macrophages (MDMs) was performed, and 1,145 differentially expressed lncRNAs were iden...

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Bibliographic Details
Main Authors: Ti-Chun Chao, Qiong Zhang, Zhonghan Li, Shashi Kant Tiwari, Yue Qin, Edwin Yau, Ana Sanchez, Gatikrushna Singh, Kungyen Chang, Marcus Kaul, Maile Ann Young Karris, Tariq M. Rana
Format: Article
Language:English
Published: American Society for Microbiology 2019-09-01
Series:mBio
Subjects:
long noncoding rnas
epigenetic regulation
hiv promoter
ribonucleoprotein complexes
prevention of hiv-1 recrudescence
Online Access:https://doi.org/10.1128/mBio.02016-19

Internet

https://doi.org/10.1128/mBio.02016-19

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