Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo

Therapeutic Zfra4-10 or WWOX7-21 Peptide Induces Complex Formation of WWOX with Selective Protein Targets in Organs that Leads to Cancer Suppression and Spleen Cytotoxic Memory Z Cell Activation In Vivo

Synthetic Zfra4-10 and WWOX7-21 peptides strongly suppress cancer growth in vivo. Hypothetically, Zfra4-10 binds to the membrane Hyal-2 of spleen Z cells and activates the Hyal-2/WWOX/SMAD4 signaling for cytotoxic Z cell activation to kill cancer cells. Stimulation of membrane WWOX in the signaling...

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Bibliographic Details
Main Authors: Wan-Pei Su, Wan-Jen Wang, Jean-Yun Chang, Pei-Chuan Ho, Tsung-Yun Liu, Kuang-Yu Wen, Hsiang-Ling Kuo, Yu-Jie Chen, Shenq-Shyang Huang, Dudekula Subhan, Yu-An Chen, Chen-Yu Lu, Chia-Yun Wu, Sing-Ru Lin, Ming-Hui Lee, Ming-Fu Chiang, Chun-I Sze, Nan-Shan Chang
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
Hyal-2<sup>+</sup> CD3<sup>-</sup> CD19<sup>-</sup> lymphocyte
Z lymphocyte
WWOX
phosphorylation
Zfra
Hyaluronan
Online Access:https://www.mdpi.com/2072-6694/12/8/2189

Internet

https://www.mdpi.com/2072-6694/12/8/2189

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