Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications

Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications

Adoptive T cell therapy utilizing tumor-specific autologous T cells has shown promising results for cancer treatment. However, the limited numbers of autologous tumor-associated antigen (TAA)-specific T cells and the functional aberrancies, due to disease progression or treatment, remain factors tha...

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Bibliographic Details
Main Authors: Vania Lo Presti, Annelisa M. Cornel, Maud Plantinga, Ester Dünnebach, Jurgen Kuball, Jaap Jan Boelens, Stefan Nierkens, Niek P. van Til
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
cord blood
lentiviral transduction
CD8+ T cells
T cell therapy
off-the-shelf
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050121000553

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http://www.sciencedirect.com/science/article/pii/S2329050121000553

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