Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression

Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression

Abstract Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH. However, the role of circ-ITCH in bladder cancer (BCa) was not reported. In the...

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Bibliographic Details
Main Authors: Chengdi Yang, Wenbo Yuan, Xiao Yang, Peng Li, Jingzi Wang, Jie Han, Jun Tao, Pengchao Li, Haiwei Yang, Qiang Lv, Wei Zhang
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cancer
Subjects:
circ-ITCH
Bladder cancer
miR-17
miR-224
p21
PTEN
Online Access:http://link.springer.com/article/10.1186/s12943-018-0771-7

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http://link.springer.com/article/10.1186/s12943-018-0771-7

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