Association of active γ-secretase complex with lipid rafts

Association of active γ-secretase complex with lipid rafts

Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet clear, several studies have provided evidence for the involvement of cholesterol-rich lipid rafts in the production of amyloid β peptide (Aβ), the major component of a...

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Bibliographic Details
Main Authors: Yasuomi Urano, Ikuo Hayashi, Noriko Isoo, Patrick C. Reid, Yoshikazu Shibasaki, Noriko Noguchi, Taisuke Tomita, Takeshi Iwatsubo, Takao Hamakubo, Tatsuhiko Kodama
Format: Article
Language:English
Published: Elsevier 2005-05-01
Series:Journal of Lipid Research
Subjects:
Alzheimer's disease
statin
cholesterol
isoprenylation
presenilin
nicastrin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520339730

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http://www.sciencedirect.com/science/article/pii/S0022227520339730

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