A validated antibody panel for the characterization of tau post-translational modifications

A validated antibody panel for the characterization of tau post-translational modifications

Abstract Background Tau is a microtubule-binding protein, which is subject to various post-translational modifications (PTMs) including phosphorylation, methylation, acetylation, glycosylation, nitration, sumoylation and truncation. Aberrant PTMs such as hyperphosphorylation result in tau aggregatio...

Full description

Bibliographic Details
Main Authors: Ebru Ercan, Sameh Eid, Christian Weber, Alexandra Kowalski, Maria Bichmann, Annika Behrendt, Frank Matthes, Sybille Krauss, Peter Reinhardt, Simone Fulle, Dagmar E. Ehrnhoefer
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Molecular Neurodegeneration
Subjects:
Tau
Post-translational modification
Antibody validation
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-017-0229-1

Internet

http://link.springer.com/article/10.1186/s13024-017-0229-1

Similar Items