Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization

Increased dietary consumption of docosahexaenoic acid (DHA) is associated with decreased risk for Alzheimer's disease (AD). These effects have been postulated to arise from DHA's pleiotropic effects on AD pathophysiology, including its effects on β-amyloid (Aβ) production, aggregation, and...

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Bibliographic Details
Main Authors: Edmond Teng, Karen Taylor, Tina Bilousova, David Weiland, Thaidan Pham, Xiaohong Zuo, Fusheng Yang, Ping-Ping Chen, Charles G. Glabe, Alison Takacs, Dennis R. Hoffman, Sally A. Frautschy, Gregory M. Cole
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
Docosahexaenoic acid
β-amyloid
Aggregation
Oligomers
Fibrillar
Prefibrillar
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300486

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http://www.sciencedirect.com/science/article/pii/S0969996115300486

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