Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy

Simultaneous Pathoproteomic Evaluation of the Dystrophin-Glycoprotein Complex and Secondary Changes in the mdx-4cv Mouse Model of Duchenne Muscular Dystrophy

In skeletal muscle, the dystrophin-glycoprotein complex forms a membrane-associated assembly of relatively low abundance, making its detailed proteomic characterization in normal versus dystrophic tissues technically challenging. To overcome this analytical problem, we have enriched the muscle membr...

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Bibliographic Details
Main Authors: Sandra Murphy, Michael Henry, Paula Meleady, Margit Zweyer, Rustam R. Mundegar, Dieter Swandulla, Kay Ohlendieck
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Biology
Subjects:
dystroglycan
dystrophin
dystrophinopathy
Na+/K+-ATPase
myozenin
organelle proteomics
periostin
sarcoglycan
syntrophin
tubulin
Online Access:http://www.mdpi.com/2079-7737/4/2/397

Internet

http://www.mdpi.com/2079-7737/4/2/397

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