Mechanotransduction Regulates Reprogramming Enhancement in Adherent 3D Keratocyte Cultures

Mechanotransduction Regulates Reprogramming Enhancement in Adherent 3D Keratocyte Cultures

Suspended spheroid culture using ultralow attachment plates (ULAPs) is reported to effect corneal fibroblast reprogramming. Polydimethylsiloxane (PDMS), with hydrophobic and soft substrate properties, facilitates adherent spheroid formation that promotes cellular physical reprogramming into stem-lik...

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Bibliographic Details
Main Authors: Shenyang Li, Chengcheng Ding, Yonglong Guo, Yanan Zhang, Hao Wang, Xihao Sun, Jun Zhang, Zekai Cui, Jiansu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
keratocytes
polydimethylsiloxane (PDMS)
spheroid culture
reprogramming
mechanotransduction
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2021.709488/full

Internet

https://www.frontiersin.org/articles/10.3389/fbioe.2021.709488/full

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