Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin

Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes a secreted protein that inhibits extracellular LPL and promotes adipocyte lipolysis. In Angptl4 null mice, glucocorticoid-induced adipocyte lipolysis and hepatic steatosis ar...

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Bibliographic Details
Main Authors: Taiyi Kuo, Tzu-Chieh Chen, Stephanie Yan, Fritz Foo, Cecilia Ching, Allison McQueen, Jen-Chywan Wang
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Journal of Lipid Research
Subjects:
glucocorticoid receptor
forkhead box protein O1
chromatin immunoprecipitation
glucocorticoid response element
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375106

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http://www.sciencedirect.com/science/article/pii/S0022227520375106

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