LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.
We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC1819564?pdf=render |