LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cleaves LPS-induced CXC chemokine (LIX) at Ser(4)-Val...

Full description

Bibliographic Details
Main Authors: Angus M Tester, Jennifer H Cox, Andrea R Connor, Amanda E Starr, Richard A Dean, Xose S Puente, Carlos López-Otín, Christopher M Overall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1819564?pdf=render

Internet

http://europepmc.org/articles/PMC1819564?pdf=render

Similar Items