Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers.

Nuclear IGF1R interact with PCNA to preserve DNA replication after DNA-damage in a variety of human cancers.

Nuclear IGF1R has been linked to poor outcome in cancer. We recently showed that nuclear IGF1R phosphorylates PCNA and increases DNA damage tolerance. In this paper we aimed to describe this mechanism in cancer tissue as well as in cancer cell lines. In situ proximity ligation assay identified frequ...

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Bibliographic Details
Main Authors: Chen Yang, Yifan Zhang, Yi Chen, Franziska Ragaller, Mingzhi Liu, Sara Corvigno, Hanna Dahlstrand, Joseph Carlson, Zihua Chen, Anders Näsman, Ahmed Waraky, Yingbo Lin, Olle Larsson, Felix Haglund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0236291

Internet

https://doi.org/10.1371/journal.pone.0236291

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