Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Modeling polymorphic ventricular tachycardia at rest using patient-specific induced pluripotent stem cell-derived cardiomyocytes

Background: While mutations in the cardiac type 2 ryanodine receptor (RyR2) have been linked to exercise-induced or catecholaminergic polymorphic ventricular tachycardia (CPVT), its association with polymorphic ventricular tachycardia (PMVT) occurring at rest is unclear. We aimed at constructing a p...

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Bibliographic Details
Main Authors: Yvonne Sleiman, Monia Souidi, Ritu Kumar, Ellen Yang, Fabrice Jaffré, Ting Zhou, Albin Bernardin, Steve Reiken, Olivier Cazorla, Andrey V. Kajava, Adrien Moreau, Jean-Luc Pasquié, Andrew R. Marks, Bruce B. Lerman, Shuibing Chen, Jim W. Cheung, Todd Evans, Alain Lacampagne, Albano C. Meli
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
PMVT
Ryanodine receptor
hiPSC-derived cardiomyocytes
Calcium handling
Contractile properties
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642030400X

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http://www.sciencedirect.com/science/article/pii/S235239642030400X

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