A Dynamic Bayesian Network model for the simulation of Amyotrophic Lateral Sclerosis progression

Abstract Background Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease progressively affecting upper and lower motor neurons in the brain and spinal cord. Mean life expectancy is three to five years, with paralysis of muscles, respiratory failure and loss of vital functi...

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Bibliographic Details
Main Authors: Alessandro Zandonà, Rosario Vasta, Adriano Chiò, Barbara Di Camillo
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Bioinformatics
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12859-019-2692-x