Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

Biosensors Show the Pharmacokinetics of S-Ketamine in the Endoplasmic Reticulum

The target for the “rapid” (<24 h) antidepressant effects of S-ketamine is unknown, vitiating programs to rationally develop more effective rapid antidepressants. To describe a drug’s target, one must first understand the compartments entered by the drug, at all levels—the organ, the cell, an...

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Bibliographic Details
Main Authors: Kallol Bera, Aron Kamajaya, Amol V. Shivange, Anand K. Muthusamy, Aaron L. Nichols, Philip M. Borden, Stephen Grant, Janice Jeon, Elaine Lin, Ishak Bishara, Theodore M. Chin, Bruce N. Cohen, Charlene H. Kim, Elizabeth K. Unger, Lin Tian, Jonathan S. Marvin, Loren L. Looger, Henry A. Lester
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
antidepressants
organelles
green fluorescent protein
protein engineering and design
periplasmic binding proteins (PBPs)
inside-out pharmacology
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00499/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00499/full

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