Isoniazid metabolism and hepatotoxicity

Isoniazid metabolism and hepatotoxicity

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations wit...

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Bibliographic Details
Main Authors: Pengcheng Wang, Komal Pradhan, Xiao-bo Zhong, Xiaochao Ma
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Isoniazid
Metabolism
Hepatotoxicity
Anti-tuberculosis
N-Acetyltransferase 2
Amidase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516301277
Description
Summary:Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.
ISSN:2211-3835
2211-3843

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