Isoniazid metabolism and hepatotoxicity

Isoniazid metabolism and hepatotoxicity

Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations wit...

Full description

Bibliographic Details
Main Authors: Pengcheng Wang, Komal Pradhan, Xiao-bo Zhong, Xiaochao Ma
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Isoniazid
Metabolism
Hepatotoxicity
Anti-tuberculosis
N-Acetyltransferase 2
Amidase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516301277
id doaj-439e28328d654c8f9d3ddc334eb53a29
record_format Article
spelling doaj-439e28328d654c8f9d3ddc334eb53a292020-11-24T23:43:37ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432016-09-016538439210.1016/j.apsb.2016.07.014Isoniazid metabolism and hepatotoxicityPengcheng Wang0Komal Pradhan1Xiao-bo Zhong2Xiaochao Ma3Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USACenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USADepartment of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT 06269, USACenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USAIsoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.http://www.sciencedirect.com/science/article/pii/S2211383516301277IsoniazidMetabolismHepatotoxicityAnti-tuberculosisN-Acetyltransferase 2Amidase
collection DOAJ
language English
format Article
sources DOAJ
author Pengcheng Wang
Komal Pradhan
Xiao-bo Zhong
Xiaochao Ma
spellingShingle Pengcheng Wang
Komal Pradhan
Xiao-bo Zhong
Xiaochao Ma
Isoniazid metabolism and hepatotoxicity
Acta Pharmaceutica Sinica B
Isoniazid
Metabolism
Hepatotoxicity
Anti-tuberculosis
N-Acetyltransferase 2
Amidase
author_facet Pengcheng Wang
Komal Pradhan
Xiao-bo Zhong
Xiaochao Ma
author_sort Pengcheng Wang
title Isoniazid metabolism and hepatotoxicity
title_short Isoniazid metabolism and hepatotoxicity
title_full Isoniazid metabolism and hepatotoxicity
title_fullStr Isoniazid metabolism and hepatotoxicity
title_full_unstemmed Isoniazid metabolism and hepatotoxicity
title_sort isoniazid metabolism and hepatotoxicity
publisher Elsevier
series Acta Pharmaceutica Sinica B
issn 2211-3835
2211-3843
publishDate 2016-09-01
description Isoniazid (INH) is highly effective for the management of tuberculosis. However, it can cause liver injury and even liver failure. INH metabolism has been thought to be associated with INH-induced liver injury. This review summarized the metabolic pathways of INH and discussed their associations with INH-induced liver injury.
topic Isoniazid
Metabolism
Hepatotoxicity
Anti-tuberculosis
N-Acetyltransferase 2
Amidase
url http://www.sciencedirect.com/science/article/pii/S2211383516301277
work_keys_str_mv AT pengchengwang isoniazidmetabolismandhepatotoxicity
AT komalpradhan isoniazidmetabolismandhepatotoxicity
AT xiaobozhong isoniazidmetabolismandhepatotoxicity
AT xiaochaoma isoniazidmetabolismandhepatotoxicity
_version_ 1725500995662774272

Similar Items