Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir
Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing typ...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-03-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/31919 |