Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing typ...

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Bibliographic Details
Main Authors: Alex C Stabell, Nicholas R Meyerson, Rebekah C Gullberg, Alison R Gilchrist, Kristofor J Webb, William M Old, Rushika Perera, Sara L Sawyer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
zoonosis
viral reservoir
interferon
Online Access:https://elifesciences.org/articles/31919

Internet

https://elifesciences.org/articles/31919

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