Polysulfide protects midbrain dopaminergic neurons from MPP+-induced degeneration via enhancement of glutathione biosynthesis

Polysulfides are endogenous sulfur-containing molecular species that may regulate various cellular functions. Here we examined the effect of polysulfides exogenously applied to rat midbrain slice cultures, to address their potential neuroprotective actions. Na2S3 at concentrations of 10 μM or higher...

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Bibliographic Details
Main Authors: Shuhei Takahashi, Akinori Hisatsune, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861318300719