Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis

Hypoxia Promotes a Mixed Inflammatory-Fibrotic Macrophages Phenotype in Active Sarcoidosis

BackgroundMacrophages are pivotal cells in sarcoidosis. Monocytes-derived (MD) macrophages have recently been demonstrated to play a major role especially in pulmonary sarcoidosis. From inflammatory tissues to granulomas, they may be exposed to low oxygen tension environments. As hypoxia impact on s...

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Bibliographic Details
Main Authors: Florence Jeny, Jean-François Bernaudin, Dominique Valeyre, Marianne Kambouchner, Marina Pretolani, Hilario Nunes, Carole Planès, Valérie Besnard
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
pulmonary sarcoidosis
hypoxia-inducible factor 1
plasminogen activator inhibitor-1
macrophages
fibrosis
monocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.719009/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.719009/full

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