Abnormal motor phenotype in the SMNΔ7 mouse model of spinal muscular atrophy

Abnormal motor phenotype in the SMNΔ7 mouse model of spinal muscular atrophy

Spinal muscular atrophy (SMA) is a recessive motor neuron disease that affects motor neurons in the anterior horn of the spinal cord. SMA results from the reduction of SMN (survival motor neuron) protein. Even though SMN is ubiquitously expressed, motor neurons are more sensitive to the reduction in...

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Bibliographic Details
Main Authors: Matthew E.R. Butchbach, Jonathan D. Edwards, Arthur H.M. Burghes
Format: Article
Language:English
Published: Elsevier 2007-08-01
Series:Neurobiology of Disease
Subjects:
Spinal muscular atrophy
Motor neuron disease
Behavior
Development
Sample size estimation
Fox battery
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107000903

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http://www.sciencedirect.com/science/article/pii/S0969996107000903

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