Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor

Reactive astrocytosis-induced perturbation of synaptic homeostasis is restored by nerve growth factor

Reactive gliosis has been implicated in both inflammatory and neurodegenerative diseases. However, mechanisms by which astrocytic activation affects synaptic efficacy have been poorly elucidated. We have used the spared nerve injury (SNI) of the sciatic nerve to induce reactive astrocytosis in the l...

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Bibliographic Details
Main Authors: Giovanni Cirillo, Maria Rosaria Bianco, Anna Maria Colangelo, Carlo Cavaliere, De Luca Daniele, Laura Zaccaro, Lilia Alberghina, Michele Papa
Format: Article
Language:English
Published: Elsevier 2011-03-01
Series:Neurobiology of Disease
Subjects:
Nerve Growth Factor
Nerve injury
Neuro-glial network
Reactive astrocytosis
Synaptic homeostasis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110003876

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http://www.sciencedirect.com/science/article/pii/S0969996110003876

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