Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.

Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.

Many of the neurodegenerative diseases that afflict people in later life are associated with the formation of protein aggregates. These so-called "proteinopathies" include Alzheimer's disease (AD) and Huntington's disease (HD). The insulin/insulin-like growth factor signalling (I...

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Bibliographic Details
Main Authors: Silvia Corrochano, Maurizio Renna, Georgina Osborne, Sarah Carter, Michelle Stewart, Joel May, Gillian P Bates, Steve D M Brown, David C Rubinsztein, Abraham Acevedo-Arozena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25140802/pdf/?tool=EBI

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