TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we characterize these centriolar protein assemblies...

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Bibliographic Details
Main Authors: Fernando R Balestra, Andrés Domínguez-Calvo, Benita Wolf, Coralie Busso, Alizée Buff, Tessa Averink, Marita Lipsanen-Nyman, Pablo Huertas, Rosa M Ríos, Pierre Gönczy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
TRIM37 E3 ligase
Mulibrey nanism
Centriole
microtubule organizing center
centrobin
CLEM
Online Access:https://elifesciences.org/articles/62640

Internet

https://elifesciences.org/articles/62640

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