The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial.
Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD...
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doaj-43c9c0096a6b4f3da4251ef70f0d25652020-11-25T03:19:30ZengMDPI AGNutrients2072-66432020-03-0112370810.3390/nu12030708nu12030708The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial.Valentina Ciappolino0Giuseppe DelVecchio1Cecilia Prunas2Angela Andreella3Livio Finos4Elisabetta Caletti5Francesca Siri6Alessandra Mazzocchi7Andrea Botturi8Stefano Turolo9Carlo Agostoni10Paolo Brambilla11Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, ItalyDepartment of Pathophysiology and Transplantation, University of Milan, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, ItalyDepartment of Statistical Sciences, University of Padua, 35100 Padua, ItalyDepartment of Developmental Psychology and Socialization, University of Padua, 35100 Padua, ItalyFondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyNeurologic Clinic, Fondazione IRCCS Istituto neurologico Carlo Besta, 20133 Milan, ItalyFondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Pediatric Nephrology, Dialysis and Transplant Unit, 20122 Milan, ItalyDepartment of Clinical Sciences and Community Health, University of Milan, 20122 Milan, ItalyFondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, ItalyBipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i>z</i> = 3.9, <i>p</i> = 0.003) or BD with placebo (<i>t </i>= 3.7, <i>p</i> = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD.https://www.mdpi.com/2072-6643/12/3/708bipolar disorderdocosahexaenoic acidω-3 long chain polyunsaturated fatty acidscognitive functions |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Valentina Ciappolino Giuseppe DelVecchio Cecilia Prunas Angela Andreella Livio Finos Elisabetta Caletti Francesca Siri Alessandra Mazzocchi Andrea Botturi Stefano Turolo Carlo Agostoni Paolo Brambilla |
spellingShingle |
Valentina Ciappolino Giuseppe DelVecchio Cecilia Prunas Angela Andreella Livio Finos Elisabetta Caletti Francesca Siri Alessandra Mazzocchi Andrea Botturi Stefano Turolo Carlo Agostoni Paolo Brambilla The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. Nutrients bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions |
author_facet |
Valentina Ciappolino Giuseppe DelVecchio Cecilia Prunas Angela Andreella Livio Finos Elisabetta Caletti Francesca Siri Alessandra Mazzocchi Andrea Botturi Stefano Turolo Carlo Agostoni Paolo Brambilla |
author_sort |
Valentina Ciappolino |
title |
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
title_short |
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
title_full |
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
title_fullStr |
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
title_full_unstemmed |
The Effect of DHA Supplementation on Cognition in Patients with Bipolar Disorder: An Exploratory Randomized Control Trial. |
title_sort |
effect of dha supplementation on cognition in patients with bipolar disorder: an exploratory randomized control trial. |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-03-01 |
description |
Bipolar disorder (BD) is a severe mental disorder with a wide range of cognitive deficits, both in the euthymic and acute phase of the disease. Interestingly, in recent years, there has been a growing interest in investigating the impact of ω-3 polyunsaturated fatty acids on cognition in BD. In this context, the aim of this study is to evaluate the effect of docosahexaenoic acid (C22:6 ω-3, DHA) supplementation on cognitive performances in euthymic BD patients. This is an exploratory, single-centre, double-blind randomized controlled trial evaluating 12 weeks DHA supplementation (1250 mg daily) vs. a placebo (corn oil) in 31 euthymic BD patients compared to 15 healthy controls (HCs) on cognitive functions, assessed by the Brief Assessment of Cognition in Affective Disorder (BAC-A). Plasma levels of DHA were measured. After 12 weeks of treatment, no significant group differences were observed in all neuropsychological tests between the four groups, except for the emotion inhibition test, where HCs with DHA had higher scores compared to either BD with DHA (<i>z</i> = 3.9, <i>p</i> = 0.003) or BD with placebo (<i>t </i>= 3.7, <i>p</i> = 0.005). Although our results showed that DHA could be effective for ameliorating cognition in healthy subjects, future studies are still needed to clarify the impact of DHA on cognition in BD. |
topic |
bipolar disorder docosahexaenoic acid ω-3 long chain polyunsaturated fatty acids cognitive functions |
url |
https://www.mdpi.com/2072-6643/12/3/708 |
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