Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp

Patch-Clamp Recording from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Improving Action Potential Characteristics through Dynamic Clamp

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) hold great promise for studying inherited cardiac arrhythmias and developing drug therapies to treat such arrhythmias. Unfortunately, until now, action potential (AP) measurements in hiPSC-CMs have been hampered by the virtual ab...

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Bibliographic Details
Main Authors: Arie O. Verkerk, Christiaan C. Veerman, Jan G. Zegers, Isabella Mengarelli, Connie R. Bezzina, Ronald Wilders
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:International Journal of Molecular Sciences
Subjects:
induced pluripotent stem cells
differentiation
retinoic acid
cardiomyocytes
electro-physiology
inward rectifier potassium current
perforated patch-clamp
computer simulations
Online Access:https://www.mdpi.com/1422-0067/18/9/1873

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https://www.mdpi.com/1422-0067/18/9/1873

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