Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis

Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis

The GABAB receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in a number of disorders including Multiple Sclerosis (MS), but its precise mechanism of action is unknown. Neuroinflammation drives the central pathology in MS and is mediated by both immunorea...

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Bibliographic Details
Main Authors: Tadhg eCrowley, John Mark eFitzpatrick, Teun eKuijper, John F Cryan, Orna eO'Toole, Olivia eO'leary, Eric eDowner
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Baclofen
Inflammation
Multiple Sclerosis
GABA
innate immunity
glia
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00284/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00284/full

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