Improved scFv Anti-HIV-1 p17 Binding Affinity Guided from the Theoretical Calculation of Pairwise Decomposition Energies and Computational Alanine Scanning

Improved scFv Anti-HIV-1 p17 Binding Affinity Guided from the Theoretical Calculation of Pairwise Decomposition Energies and Computational Alanine Scanning

Computational approaches have been used to evaluate and define important residues for protein-protein interactions, especially antigen-antibody complexes. In our previous study, pairwise decomposition of residue interaction energies of single chain Fv with HIV-1 p17 epitope variants has indicated th...

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Bibliographic Details
Main Authors: Panthip Tue-ngeun, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Narin Lawan, Sawitree Nangola, Chatchai Tayapiwatana, Noorsaadah Abdul Rahman, Sharifuddin Md. Zain, Vannajan Sanghiran Lee
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2013/713585

Internet

http://dx.doi.org/10.1155/2013/713585

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